Articles Tagged With:
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Withdrawing Heart Failure Medications After Restoring Sinus Rhythm in AF Cardiomyopathy Patients
A small trial of withdrawing guideline-directed medical therapy (GDMT) for reduced ejection fraction (EF) heart failure in patients with atrial fibrillation in whom EF recovered after restoration of normal sinus rhythm has shown that withdrawal of GDMT was not associated with a decline in EF over 12 months in most patients.
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Beta-Blocker Interruption Post-MI
An analysis of the secondary outcomes in the French multicentered study of beta-blocker withdrawal in patients with uncomplicated myocardial infarction after one year led to increases in heart rate and blood pressure with potentially deleterious outcomes, especially in patients with a history of hypertension.
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Routine CCTA Imaging of Left Main PCI Patients Falls Short in Randomized Trial
In this randomized trial of patients undergoing left main percutaneous coronary intervention, routine surveillance coronary computed tomography angiography six months after intervention did not reduce the composite endpoint of all-cause death, myocardial infarction (MI), unstable angina, or stent thrombosis at 18 months, but was associated with fewer spontaneous MIs and more imaging-triggered revascularization procedures.
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Diabetic Emergencies
Although diabetes affects various organ systems and complicates other disease processes, pure diabetic emergencies include diabetic ketoacidosis, hyperosmolar hyperglycemic syndrome, euglycemic diabetic ketoacidosis, and severe hypoglycemia. These emergencies often are precipitated in a patient with known diabetes but frequently can be the initial presentation in someone with undiagnosed diabetes. It is essential for ED providers to understand the pathophysiology, clinical features, workup, and management of these conditions, since they can be fatal, as they often were before the availability of insulin.
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Treated as Aberrant SVT
I was given this electrocardiogram without knowing details of the history beyond that the patient was an older man who was hemodynamically stable. He was being treated on the assumption that the rhythm was a supraventricular tachycardia with QRS widening because of aberrant conduction. Do you agree with this assumption? How certain are you of your answer
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Sunvozertinib (Zegfrovy) Tablets
The U.S. Food and Drug Administration (FDA) has granted an accelerated approval to sunvozertinib, a third-generation epidermal growth factor receptor tyrosine kinase inhibitor (EGFR-TKI) for the treatment of non-small cell lung cancer with epidermal growth factor receptor (EGFR) exon 20 insertion mutations (EGFR exon20ins). The FDA also approved a companion diagnostic device, Oncomine Dx Express Test to help detect exon20ins mutations.
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Treatment Window for Lowering Blood Pressure in Acute ICH
Effective treatment for acute intracerebral hemorrhage (ICH) has remained elusive, with inconclusive results from surgical evacuations, as well as blood pressure management. The investigators performed a pooled analysis of four INTERACT trials that studied the effect of aggressive blood pressure lowering in patients with acute ICH. Ultra-early treatment (< 3 hours from onset) may be beneficial, but most patients are not so quickly diagnosed or treated.
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Routine Boosting Against Tetanus and Diphtheria in Adults: A Time to Reconsider
Slifka and colleagues make a strong argument against the routine booster vaccination of adults against tetanus and diphtheria as recommended by the Centers for Disease Control and Prevention.
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MIND Matters: Diet, Exercise, and Engagement in Cognitive Health
This multicenter, randomized clinical trial showed that a highly structured, multidomain lifestyle intervention modestly but significantly was associated with improved global cognitive function throughout two years in at-risk older adults, compared to a lower-intensity, self-guided program.
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Gabapentin and the Risk of Dementia in Adults with Chronic Pain
In a retrospective cohort study, gabapentin prescription in adults with chronic low back pain was associated with increased risk of dementia and cognitive impairment, particularly in non-elderly adults.